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A study carried out by Professor Anirban Bhunia and his team at the Bose Institute in Kolkata, an autonomous institute of the Department of Science and Technology, has revealed that Lasunadya Ghrita from Ayurveda, the ancient traditional Indian medicine, was more effective in inhibiting neurodegenerative diseases like Alzheimer’s Disease, Dementia, and related diseases compared to chemically designed compounds. 

These diseases are characterized by Amyloidosis which happens due to deposits of an extracellular proteinaceous material (amyloid) in tissues. Synthetically designed peptides play a pivotal role in the inhibition of various kinds of amyloidosis and thus in the suppression of the said neurodegenerative diseases. 

In their study, Professor Anirban Bhunia and his team employed two distinct strategies. First, they utilized chemically synthesized peptides to combat Amyloidosis. Second, they repurposed a drug called Lasunadya Ghrita from Ayurveda, the ancient traditional Indian medicine, which has previously shown efficacy in treating depression-related mental illnesses.

Remarkably it was found that the water extract of the non-toxic compounds of LG and their components demonstrated greater efficacy in breaking down amyloid aggregates into non-toxic smaller degradable molecules compared to the chemically designed peptides, suggesting its novel role in disaggregating amyloid-prone proteins.

Additionally, Professor Bhunia, in collaboration with Ayurveda expert Professor Dr Sanjeev Rastogi from the State Ayurvedic College and Hospital at Lucknow University, along with other researchers from the Saha Institute of Nuclear Physics, demonstrated how these natural compounds can enhance the inhibition and breakdown of amyloid beta more effectively than the chemically designed peptides. Their findings were published in the esteemed journal Biophysical Chemistry (Elsevier).

This research offers hope to individuals suffering from Alzheimer’s disease and highlights the potential of Ayurveda, or ancient Indian traditional medicine, as a viable solution to complex neurodegenerative disorders like Alzheimer’s. It may inspire further exploration into natural remedies, improving the quality of life for those affected by dementia.

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